Name | Tri-n-propyl orthoformate |
Synonyms | TNPOF TRIPROPOXYMETHANE n-Propyl orthoformate TRIPROPYL ORTHOFORMATE TRI-N-PROPYL ORTHOFORMATE Tri-n-propyl orthoformate ORTHOFORMIC TRIPROPYL ESTER 1-(dipropoxymethoxy)propane ORTHOFORMIC ACID TRIPROPYL ESTER ORTHOFORMIC ACID TRI-N-PROPYL ESTER 1,1′,1′′-[Methylidyntris(oxy)]trispropan |
CAS | 621-76-1 |
EINECS | 210-704-1 |
InChI | InChI=1/C10H22O3/c1-4-7-11-10(12-8-5-2)13-9-6-3/h10H,4-9H2,1-3H3 |
Molecular Formula | C10H22O3 |
Molar Mass | 190.28 |
Density | 0.883 g/mL at 25 °C (lit.) |
Boling Point | 106-108 °C/40 mmHg (lit.) |
Flash Point | 162°F |
Vapor Presure | 0.389mmHg at 25°C |
Appearance | Liquid |
Specific Gravity | 0.883 |
Color | Clear colorless |
BRN | 1744249 |
Storage Condition | Room Temprature |
Sensitive | Moisture Sensitive |
Refractive Index | n20/D 1.407(lit.) |
MDL | MFCD00015214 |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
UN IDs | 1993 |
WGK Germany | 1 |
FLUKA BRAND F CODES | 10-21 |
TSCA | Yes |
HS Code | 29159000 |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Product use | tripropyl orthoformate is an ester compound, which is an important chemical and pharmaceutical intermediate. |
preparation method | the process conditions for synthesizing tripropyl orthoformate from hydrocyanic acid, hydrochloric acid gas and N-propanol are as follows: in the presence of H3 solvent, the amount of catalyst is 0.5% ,n (hydrocyanic acid) ∶ n (hydrochloric acid gas) = 1 ∶ 1.15, and the reaction temperature is 5~15 ℃, when the alcoholysis temperature was 40~50 ℃ and the reaction time was 4 h, the yield was 94% . The reaction has the advantages of mild conditions, easy operation, easy control and high yield. It is an ideal method for the synthesis of tripropyl orthoformate and has great industrial value. |